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The recommended dose of Tasigna for children, regardless of what they’re using the drug to treat, is 230 mg/m 2. Your child’s doctor will calculate their dose of Tasigna using. The doctor will round the dose to the nearest 50 mg. Dose-limiting toxicity (Grade 3 fatigue) and Grade 3 hypertension were each observed in 1 of 3 patients dosed at 2000 mg daily and 1000 mg daily, respectively. While you are taking Tasigna 200Mg Capsule, avoid eating grapefruit or drinking its juice, primarily because it may hinder with the effectiveness of the drug Tasigna 200mg Capsules (Hard Gelatin) Start initial dose at 300 mg BID; if tolerated, may increase to 400 mg BID Severe hepatic impairment:. Take Tasigna on an empty stomach. Pharmaceutical form Hard capsule. Crushing or chewing it will make it less effective. Find out about Tasigna 200mg Capsule benefits, side effects, price, dose, how to use Tasigna 200mg Capsule, interactions and contraindications. The capsule should be swallowed entirely. The dose is 230 mg per square meter (m 2) twice daily. Tasigna 200 mg hard capsules One hard capsule contains 200 mg nilotinib (as hydrochloride monohydrate). For the full list of excipients, see section 6. Before taking this medicine You should not use Tasigna if you are allergic to nilotinib, or if you have: low blood levels of potassium or magnesium; or a heart rhythm disorder called long QT syndrome Pazopanib doses up to 2000 mg have been evaluated in clinical trials. Patient on strong CYP3A4 inhibitor: Reduce dose to 300 mg once daily, or to 200 mg once daily in newly-diagnosed chronic phase Philadelphia chronic myelogenous leukaemia. Digoxin Patient on strong CYP3A4 inhibitor: Reduce dose to 300 mg once daily, or to 200 mg once daily in newly-diagnosed chronic phase Philadelphia chronic myelogenous leukaemia. Nilotinib will increase the level or effect of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Once you take TASIGNA, you just have to wait 1 hour to eat breakfast. The drug works best if the doses are taken after every 12 hours. Avoid eating anything for at least 2 hours before and 1 hour after you take your dose. Treatment of overdose with Nilotinib should consist of general supportive measures Tasigna 200mg Capsules (Hard Gelatin) Start initial dose at 300 mg BID; if tolerated, may increase to 400 mg BID Severe hepatic impairment:. Excipient with known effect One hard capsule contains 156. This amount is rounded to the nearest 50 mg dose up to a maximum of 400 mg. If needed, attain the desired dose by combining different strengths of Tasigna capsules Take TASIGNA when you wake up: Some people find it helpful to take TASIGNA as soon as they wake up in the morning since they haven’t had any food for 2 hours or more. The recommended dosage of Tasigna for pediatric patients is 230 mg/m 2 orally twice daily, rounded to the nearest 50 mg dose (to a maximum single dose of 400 mg) (see Table 1). Monitor for potential adverse effects such as nausea, irregular uterine bleeding, breast tenderness and headache. Be sure to allow 12 hours before you take your second dose of the day The recommended dose of Tasigna for children, regardless of what they’re using the drug to treat, is 230 mg/m 2.

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